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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: AKT1 All Species: 33.94
Human Site: S246 Identified Species: 67.88
UniProt: P31749 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P31749 NP_001014431.1 480 55686 S246 L S R E R V F S E D R A R F Y
Chimpanzee Pan troglodytes XP_512662 481 55720 T248 L S R E R V F T E E R A R F Y
Rhesus Macaque Macaca mulatta XP_001085623 480 55679 S246 L S R E R V F S E D R A R F Y
Dog Lupus familis XP_548000 481 55446 P247 L S R E R V F P E D R A R F Y
Cat Felis silvestris
Mouse Mus musculus P31750 480 55604 S246 L S R E R V F S E D R A R F Y
Rat Rattus norvegicus P47196 480 55717 S246 L S R E R V F S E D R A R F Y
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513899 512 59226 S286 L S R E R V F S E D R T R F Y
Chicken Gallus gallus Q6U1I9 432 48872 H215 A S A L G Y L H S L N I V Y R
Frog Xenopus laevis Q98TY9 481 56023 S247 L S R E R I F S E D R A R F Y
Zebra Danio Brachydanio rerio Q7ZTW4 433 48964 H216 A S A L G Y L H S L N I V Y R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q8INB9 611 68466 T362 L S H E R I F T E D R T R F Y
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q17941 541 62181 S289 V R K C G T F S E P R A R F Y
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 81.5 99.5 93.9 N.A. 98.1 98.1 N.A. 73 39.7 93.1 39.3 N.A. 49.5 N.A. 52.5 N.A.
Protein Similarity: 100 92 99.5 95.2 N.A. 98.7 99.1 N.A. 80.4 56.8 96.2 57.5 N.A. 61.7 N.A. 67.8 N.A.
P-Site Identity: 100 86.6 100 93.3 N.A. 100 100 N.A. 93.3 6.6 93.3 6.6 N.A. 73.3 N.A. 53.3 N.A.
P-Site Similarity: 100 100 100 93.3 N.A. 100 100 N.A. 93.3 13.3 100 13.3 N.A. 86.6 N.A. 66.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 17 0 17 0 0 0 0 0 0 0 0 67 0 0 0 % A
% Cys: 0 0 0 9 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 67 0 0 0 0 0 % D
% Glu: 0 0 0 75 0 0 0 0 84 9 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 84 0 0 0 0 0 0 84 0 % F
% Gly: 0 0 0 0 25 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 9 0 0 0 0 17 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 17 0 0 0 0 0 17 0 0 0 % I
% Lys: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 75 0 0 17 0 0 17 0 0 17 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 17 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 9 0 9 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 9 67 0 75 0 0 0 0 0 84 0 84 0 17 % R
% Ser: 0 92 0 0 0 0 0 59 17 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 9 0 17 0 0 0 17 0 0 0 % T
% Val: 9 0 0 0 0 59 0 0 0 0 0 0 17 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 17 0 0 0 0 0 0 0 17 84 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _